abstract：:We know very little about the change in pain in the first 2 months after surgery. To address this gap, we studied 530 women scheduled for elective cesarean delivery who completed daily pain diaries for 2 months after surgery through text messaging. Over 82% of subjects missed fewer than 10 diary entries and were inclu...

journal_title：Pain

authors： Booth JL,Sharpe EE,Houle TT,Harris L,Curry RS,Aschenbrenner CA,Eisenach JC

更新日期：2018-10-01 00:00:00

abstract：:In knee osteoarthritis (OA), pain sensitization has been linked to a more severe symptomatology, but the prognostic implications of pain sensitivity in people undergoing conservative treatment such as physiotherapy are not established. This study aimed to prospectively investigate the association between features of p...

journal_title：Pain

authors： OʼLeary H,Smart KM,Moloney NA,Blake C,Doody CM

更新日期：2018-09-01 00:00:00

abstract：:Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice: spinal mechanisms underlying nerve injury-induced allodynia are microglial dependent in male but not female mice. Whe...

journal_title：Pain

authors： Mapplebeck JCS,Dalgarno R,Tu Y,Moriarty O,Beggs S,Kwok CHT,Halievski K,Assi S,Mogil JS,Trang T,Salter MW

更新日期：2018-09-01 00:00:00

abstract：:Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly...

journal_title：Pain

authors： Zhang H,Lund DM,Ciccone HA,Staatz WD,Ibrahim MM,Largent-Milnes TM,Seltzman HH,Spigelman I,Vanderah TW

更新日期：2018-09-01 00:00:00

abstract：:In humans, chronic psychological stress is associated with increased intestinal paracellular permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent water avoidance stress (WAS) rat model. However, it is unknown whether enhanced visceral pain and permeability are intrinsically linked...

journal_title：Pain

authors： Creekmore AL,Hong S,Zhu S,Xue J,Wiley JW

更新日期：2018-09-01 00:00:00

abstract：:Expectations modulate the subjective experience of pain by increasing sensitivity to nociceptive inputs, an effect mediated by brain regions such as the insula. However, it is still unknown whether the neural structures underlying pain expectancy hold sensory-specific information or, alternatively, code for modality-i...

journal_title：Pain

authors： Sharvit G,Corradi-DellʼAcqua C,Vuilleumier P

更新日期：2018-08-01 00:00:00

abstract：:Concerns over prescription opioids contributing to high levels of opioid use disorder and overdose have led policymakers and clinicians to seek means to reduce inappropriate and high-dose initial prescriptions. To inform such efforts, we sought to describe the clinical indications associated with opioid initiation and...

journal_title：Pain

authors： Pasricha SV,Tadrous M,Khuu W,Juurlink DN,Mamdani MM,Paterson JM,Gomes T

更新日期：2018-08-01 00:00:00

abstract：:Abnormal endogenous pain modulation was suggested as a potential mechanism for chronic pain, ie, increased pain facilitation and/or impaired pain inhibition underlying symptoms manifestation. Endogenous pain modulation function can be tested using psychophysical methods such as temporal summation of pain (TSP) and con...

journal_title：Pain

authors： Moana-Filho EJ,Herrero Babiloni A,Theis-Mahon NR

更新日期：2018-08-01 00:00:00

abstract：:The neurochemical effects of adenosine signaling in small-fiber neuropathy leading to neuropathic pain are yet to be explored in a direct manner. This study examined this system at the level of ligand (through the ectonucleotidase activity of prostatic acid phosphatase [PAP]) and adenosine A1 receptors (A1Rs) in resin...

journal_title：Pain

authors： Kan HW,Chang CH,Lin CL,Lee YC,Hsieh ST,Hsieh YL

更新日期：2018-08-01 00:00:00

abstract：:Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous s...

journal_title：Pain

authors： Clark AJ,Menendez G,AlQatari M,Patel N,Arstad E,Schiavo G,Koltzenburg M

更新日期：2018-07-01 00:00:00

abstract：:Advances in pain measurement using ecological momentary assessments offer novel opportunities for understanding the temporal dynamics of pain. This study examined whether regime-switching models, which capture processes characterized by recurrent shifts between different states, provide clinically relevant information...

journal_title：Pain

authors： Schneider S,Junghaenel DU,Ono M,Stone AA

更新日期：2018-07-01 00:00:00

abstract：:Pain has the capacity to interfere with daily tasks. Although task interference by pain is largely unintentional, it can be controlled to a certain extent. Such top-down control over pain has been believed to be reduced in patients with fibromyalgia (FM). In this study, we investigated task interference and distractio...

journal_title：Pain

authors： Van Ryckeghem DML,Rost S,Kissi A,Vögele C,Crombez G

更新日期：2018-06-01 00:00:00

abstract：:Moderate to severe chronic pain affects 1 in 5 adults and its impact increases with age. People with chronic pain that interferes with their lives have an increased risk of mortality. Identifying how interfering chronic pain can lead to mortality may highlight potential intervention strategies. This study uses a novel...

journal_title：Pain

authors： Smith D,Wilkie R,Croft P,Parmar S,McBeth J

更新日期：2018-06-01 00:00:00

abstract：:Pregnant women may take nonsteroidal antiinflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors, or biological agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to nonselective NSAIDs, selective ...

journal_title：Pain

authors： Bérard A,Sheehy O,Girard S,Zhao JP,Bernatsky S

更新日期：2018-05-01 00:00:00

abstract：:Pain scales using faces are commonly used tools for assessing pain in children capable of communicating. However, some children require other types of pain scales because they have difficulties in understanding faces pain scales. The goal of this study was to develop and validate the "Pain Block" concrete ordinal scal...

journal_title：Pain

authors： Jung JH,Lee JH,Kim DK,Jung JY,Chang I,Kwon H,Shin J,Paek SH,Oh S,Kwak YH

更新日期：2018-04-01 00:00:00

abstract：:Online educational interventions are increasingly developed for health professionals and students, although graduate and undergraduate medical curricula often contain limited information about how to assess and manage pain. This study reviews the literature on the effectiveness of pain-related online educational resou...

journal_title：Pain

authors： Liossi C,Failo A,Schoth DE,Williams G,Howard RF

更新日期：2018-04-01 00:00:00

abstract：:Primary burning mouth syndrome (BMS) is defined as an "intraoral burning or dysaesthetic sensation, recurring daily… more than 3 months, without clinically evident causative lesions" (IHS 2013). In addition to pain, taste alterations are frequent (dysgeusia, xerostomia). Although lacking clinical signs of neuropathy, ...

journal_title：Pain

authors： Jääskeläinen SK

更新日期：2018-03-01 00:00:00

abstract：:Our objectives were to determine whether procedural pain and glucose exposure are associated with altered structural and functional brain development differently in preterm males and females, and neurodevelopment at 18-month corrected age. Fifty-one very preterm neonates (22 males; median [interquartile range] gestati...

journal_title：Pain

authors： Schneider J,Duerden EG,Guo T,Ng K,Hagmann P,Bickle Graz M,Grunau RE,Chakravarty MM,Hüppi PS,Truttmann AC,Miller SP

更新日期：2018-03-01 00:00:00

abstract：:Humans require the ability to discriminate intensities of noxious stimuli to avoid future harm. This discrimination process seems to be biased by an individual's attention to pain and involves modulation of the relative intensity differences between stimuli (ie, Weber fraction). Here, we ask whether attention networks...

journal_title：Pain

authors： Yang SL,Wu TW,Tseng MT

更新日期：2018-02-01 00:00:00

abstract：:Spinal synaptic plasticity is believed to drive central sensitization that underlies the persistent nature of neuropathic pain. Our recent data showed that synaptic plasticity in the dorsal horn is cell type specific: intense afferent stimulation produced long-term potentiation (LTP) in excitatory spinothalamic tract ...

journal_title：Pain

authors： Bittar A,Jun J,La JH,Wang J,Leem JW,Chung JM

更新日期：2017-11-01 00:00:00

abstract：:Pain catastrophizing is a significant risk factor for patients with knee osteoarthritis (KOA) and thus is a target for many psychological interventions for pain. This study examined if interventions targeting sleep found to be effective in improving sleep in KOA also reduce pain catastrophizing measured as a trait thr...

journal_title：Pain

authors： Lerman SF,Finan PH,Smith MT,Haythornthwaite JA

更新日期：2017-11-01 00:00:00

abstract：:Chronic or episodic severe itch is recurrent in atopic dermatitis (AD). Nonhistaminergic itch pathways are suggested to dominate in AD itch, contributing to an "itch-scratch-itch cycle" that prolongs and worsens itch, pain, and skin lesions. We hypothesized that nonhistaminergic neuronal sensitization contributes to i...

journal_title：Pain

authors： Andersen HH,Elberling J,Sølvsten H,Yosipovitch G,Arendt-Nielsen L

更新日期：2017-09-01 00:00:00

abstract：:This laboratory-based study examined lagged associations between child pain behavior and maternal responses as a function of maternal catastrophizing (CAT). Mothers completed the parent version of the Pain Catastrophizing Scale. Children participated in a validated water ingestion procedure to induce abdominal discomf...

journal_title：Pain

authors： Langer SL,Romano J,Brown JD,Nielson H,Ou B,Rauch C,Zullo L,Levy RL

更新日期：2017-09-01 00:00:00

abstract：:Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and noci...

journal_title：Pain

authors： Ichihara K,Aizawa N,Akiyama Y,Kamei J,Masumori N,Andersson KE,Homma Y,Igawa Y

更新日期：2017-08-01 00:00:00

abstract：:Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when u...

journal_title：Pain

authors： Harden RN,Maihofner C,Abousaad E,Vatine JJ,Kirsling A,Perez RSGM,Kuroda M,Brunner F,Stanton-Hicks M,Marinus J,van Hilten JJ,Mackey S,Birklein F,Schlereth T,Mailis-Gagnon A,Graciosa J,Connoly SB,Dayanim D,Massey M,Fr

更新日期：2017-08-01 00:00:00

abstract：:Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium chloride transporter, KCC2, and with increases in neuronal excitability. Here, we te...

journal_title：Pain

authors： Castro A,Li Y,Raver C,Chandra R,Masri R,Lobo MK,Keller A

更新日期：2017-07-01 00:00:00

abstract：:This study compared a remote-delivered pain management program, the Pain Course, when delivered in online and workbook formats. Participants (n = 178) were randomised into 2 groups: (1) an Internet Group (n = 84) who were provided with secure accounts to the program in an online format; or (2) a Workbook Group (n = 94...

journal_title：Pain

authors： Dear BF,Gandy M,Karin E,Ricciardi T,Fogliati VJ,McDonald S,Staples LG,Perry KN,Sharpe L,Nicholas MK,Titov N

更新日期：2017-07-01 00:00:00

abstract：:Effective assessment and management of pain in patients with cancer is strengthened by the patient's report of how much pain interferes with daily functioning. This requires a clear delineation of different levels of pain interference. We derived optimal cutpoints for differentiating between mild, moderate, and severe...

journal_title：Pain

authors： Shi Q,Mendoza TR,Dueck AC,Ma H,Zhang J,Qian Y,Bhowmik D,Cleeland CS

更新日期：2017-06-01 00:00:00

abstract：:Fibromyalgia (FM) is a common and often debilitating chronic pain condition. Research shows that symptoms of depression and anxiety are present in up to three quarters of individuals with FM. Of concern, most adults with FM cannot access traditional face-to-face cognitive behavioural pain management programs, which ar...

journal_title：Pain

authors： Friesen LN,Hadjistavropoulos HD,Schneider LH,Alberts NM,Titov N,Dear BF

更新日期：2017-04-01 00:00:00

abstract：:Animal and human studies indicate that electrical stimulation of dorsal root ganglion (DRG) neurons may modulate neuropathic pain signals. ACCURATE, a pivotal, prospective, multicenter, randomized comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome or causalgia ...

journal_title：Pain

authors： Deer TR,Levy RM,Kramer J,Poree L,Amirdelfan K,Grigsby E,Staats P,Burton AW,Burgher AH,Obray J,Scowcroft J,Golovac S,Kapural L,Paicius R,Kim C,Pope J,Yearwood T,Samuel S,McRoberts WP,Cassim H,Netherton M,Miller N

更新日期：2017-04-01 00:00:00

abstract：:Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...

journal_title：Pain

authors： Li MJ,Liu LY,Chen L,Cai J,Wan Y,Xing GG

更新日期：2017-04-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functi...

journal_title：Pain

authors： Iyengar S,Ossipov MH,Johnson KW

更新日期：2017-04-01 00:00:00

abstract：:Medical case management has improved in the past few decades, changing the dynamic interaction between depression and prevalent medical diseases. It is relevant to describe the comorbidity between depression and medical diseases to further improve the effectiveness of case management. We analyzed the data of adults ag...

journal_title：Pain

authors： Johnson K,Politis MD,Hansen AR,McKenzie LE,Duncan DT,Zhang J

更新日期：2017-04-01 00:00:00

abstract：:The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. ...

journal_title：Pain

authors： Gutierrez-Mecinas M,Bell AM,Marin A,Taylor R,Boyle KA,Furuta T,Watanabe M,Polgár E,Todd AJ

更新日期：2017-03-01 00:00:00

abstract：:Existing estimates of sociodemographic disparities in chronic pain in the United States are based on cross-sectional data, often treat pain as a binary construct, and rarely test for nonresponse or other types of bias. This study uses 7 biennial waves of national data from the Health and Retirement Study (1998-2010; n...

journal_title：Pain

authors： Grol-Prokopczyk H

更新日期：2017-02-01 00:00:00

abstract：:Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation pain to chronic residual limb pain likely involves both peripheral and central inflammatory mechanisms. As part of the Veterans Integrated Pain Evaluation Rese...

journal_title：Pain

authors： Chamessian A,Van de Ven T,Buchheit T,Hsia HL,McDuffie M,Gamazon ER,Walsh C,Bruehl S,Buckenmaier C' 3rd,Shaw A

更新日期：2017-01-01 00:00:00

abstract：:Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumo...

journal_title：Pain

authors： Forte BL,Slosky LM,Zhang H,Arnold MR,Staatz WD,Hay M,Largent-Milnes TM,Vanderah TW

更新日期：2016-12-01 00:00:00

abstract：:This study aimed to characterize the prevalence of various pain qualities in older adults with chronic nonmalignant pain and determine the association of pain quality to other pain characteristics namely: severity, interference, distribution, and pain-associated conditions. In the population-based MOBILIZE Boston Stud...

journal_title：Pain

authors： Thakral M,Shi L,Foust JB,Patel KV,Shmerling RH,Bean JF,Leveille SG

更新日期：2016-12-01 00:00:00

abstract：:Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal eti...

journal_title：Pain

authors： Slosky LM,BassiriRad NM,Symons AM,Thompson M,Doyle T,Forte BL,Staatz WD,Bui L,Neumann WL,Mantyh PW,Salvemini D,Largent-Milnes TM,Vanderah TW

更新日期：2016-11-01 00:00:00

abstract：:Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...

journal_title：Pain

authors： Halbert BT,Davis RB,Wee CC

更新日期：2016-11-01 00:00:00